We follow a strict editorial insurance policy and we have a zero - allowance insurance policy regarding any level of piracy . Our articles are resourced from reputable online pages . This article may contains scientific references . The numbers in the parentheses ( 1 , 2 , 3 ) are clickable links to match - reviewed scientific papers .
The feedback contact “ Was this Article Helpful ” on this page can be used to cover content that is not accurate , up - to - escort or questionable in any manner .
This article does not bring home the bacon aesculapian advice .
Patients with Aortic Stenosis ( AS ) can be effectively treated with nitroglycerine , but it is contraindicate because it carries a risk of risky hypotension with it . However , this is quite a traditional and theoretical supposal that nitroglycerine is contraindicate ; much it has shown quite substantial effect in the patient suffer with Aortic Stenosis . Many studies have been conducted to contemplate about the theoretic contraindications of nitroglycerine , but no such evidences or validation have been recover . There was not any hastiness of hypotension in patients with Aortic Stenosis .
What is Aortic Stenosis?
To empathize the effect of nitroglycerine on aortic Stenosis , first of all it is of import to empathize what Aortic Stenosis is and how it is treat . It is a condition in which the aortic valve constricts in sizing due to which there is insufficient flow of blood from heart to aorta . Aorta is the largest blood vas of the body and render blood to the whole body . If the aortic valve will be bad or wo n’t function the right way , this would exert extra imperativeness on the heart to pump more blood , finally weakening the heart muscles . There is a need of valve renewal for treating the Aortic Stenosis , as only medication can not treat it all .
How Does Nitro glycerin works?
If we study the result of nitroglycerine in terms of cardiac output it can be explained as follow :
Because the aortal valve is contract in size , the amount of stemma pumped from the ventricle is reduced . The drug will boil down the peripheral electric resistance resulting in the dilating of the vessels and relaxation of the heart ventricle . The load of the pith remains the same . In the aortic stenosis patients , the after incumbrance ( insistence of the heart ) is not affected by the peripheral resistivity , but by the defective valve . This defective valve is not affect by the glyceryl trinitrate . If this is lot in the patient and the vessels are expatiate without the changing in the cardiac output , the problem can increase more , the descent can drop and also the capacity to perfuse . This can even cause angina in affected role with coronary disease .
What Does A Latest Research Say?
Researchers have conducted a grouping sketch on this assumption to watch whether the incident of hypotension occurs or not in the patient role with severe , average and no aortic Stenosis . Three grouping of different age groups were shape . The first group was of the patients with grievous AS , the second group was with moderate AS and the third group was of normal people with no AS . All the three groups were administer with glyceryl trinitrate under keep in line consideration , from various routes . It was observed that the there was no associated hypotension in the severe and moderate AS patients .
Medication for Aortic Stenosis and Associated Complications
Statins : antecedently it was believed that the statins slow down the progression of aortic stenosis , but the former visitation show that there is n’t any such activity ; although a considerable reduction in the ischemic cardiovascular proceedings have been observed .
Beta blocker and Calcium Channel blockers : If there is hypertension or angina it has to be treated forthwith and sharply using calcium channel blocker or genus Beta blocker , however the administration of beta - blockers should be done cautiously .
Digoxin and Diuretics : They are used in the type of philia failure . If there is no contraindication , careful administration of ACE inhibitors can also be done .
nitrate : As stated above nitroglycerine is theoretically contraindicated in the patients with aortal Stenosis . The patient role are instructed to debar it because of their dependence on preload and precipitation of sudden hypotension .
References :
Also Read :
