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thrombocyte , also known as thrombocyte , are small-scale and global blood portion produce in the bone marrow . They are crucial for blood clotting and hemostasia . The normal levels of blood platelet in blood range from 150,000 - 450,000 per three-dimensional millimeter of blood . The normal animation span of platelet ranges from 7 to 10 daytime .
The medical term for lofty level of blood platelet is thrombocytosis . The higher normal level of thrombocyte is typically 350,000 - 450,000 per cubic millimeter of ancestry . Thrombocytosis can be detected in the routine blood test .
What Would Cause An Increase In Blood Platelets?
The causes of an increase in blood platelets or thrombocytosis can be grouped as physiological thrombocytosis , elementary ( clonal ) thrombocytosis and secondary ( reactive ) thrombocytosis .
Physiological Thrombocytosis can leave from use ( workload ) , increase adrenaline or increased stress .
Primary Thrombocytosis ( clonal ) is a result of abnormalbone marrowcells , which leads to increased platelets in circulation . Primary thrombocytosis could conduce to life-threatening hemorrhage or clot complications such as unnatural profligate clotting . This is obviate by normalizing platelet count with medications . The unlike causes include acute megakaryocytic leukemia , myeloproliferative disease , indispensable thrombocytosis , polycythemia vera , chronic myeloid leukemia , myelodysplastic syndrome and agnogenic myeloid metaplasia .
Secondary Thrombocytosis ( reactive ) may be a result of any disease or condition that may be affecting an individual . These include acute blood loss , hemolytic anemia , contagion , Fe deficiencyanemia , operation , inflammatory disease , situation splenectomy , malignant diseases , trauma or due to certain drugs such as Oncovin , trans retinoic pane , cytokines and growth factors . Secondary thrombocytosis due to any of the above cause usually subside after the intervention of the rudimentary cause . The platelet count is promote for a short period of meter after the direction of secondary cause , but it does not go to any clot complications such as unnatural rip clotting .
Polycythemia Vera : The platelet count in PV may be dramatically increase to as high as 1,000,000 per cubic millimeter of blood . About 66 % of patients with this disease have usher increase levels of platelet .
Chronic Myeloid leukaemia : In this disease , about 75 % of patients have set increase in platelet levels .
Agnogenic Myeloid Metaplasia : It is also known as myeloid metaplasia agnogenic or idiopathic myelofibrosis . Thrombocytosis is assure in about 33 % of patient role suffer from this disease ; however , thrombocytopenia is a prominent finding in advanced cases of this disease .
Essential Thrombocytosis : It is also bonk as elemental thrombocythemia . It is a chronic and myeloproliferative disease . Generally , it is an idiopathic disease , but there is a familial sensitivity too .
transmission : Secondary thrombocytosis could be a cause of acute or chronic infection in which there is inhibition of megakaryopoiesis ( formation of megakaryocytes , which are precursors to blood platelet ) due to various bacteria and virus . Few bacterial infection in which there is thrombocytosis includepneumonia , purulent arthritis , tuberculosis , pyelonephritis , osteomyelitisand inveterate wound infection .
Iron Deficiency Anemia : The platelet count in smoothing iron deficiency anemia , on occasions , may be as eminent as 1,000,000 per cubic millimetre . The platelet count usually comes back to normal with iron supplements .
Splenectomy : Spleen is responsible for the removal of platelet , so after the splenectomy there is transient increase in the number of platelet , which on fourth dimension outperform 1,000,000 per three-dimensional millimeter . broadly , the blood platelet reckoning is back to normal within a few week or calendar month . lasting thrombocytosis after the remotion of spleen may be an denotation of junior-grade thrombocytosis such as myeloproliferative disorderliness .
incitive Diseases : The rabble-rousing conditions that might cause thrombocytosis let in seditious bowel disease , liver cirrhosis , rheumatoid arthritis , rheumatic polymyalgia , nephritis and polyarteritis nodosa . The severity of the disease jibe to the badness of thrombocytosis . The thrombocyte counting does return to normal with appropriate treatment of rabble-rousing disease .
Malignant disease : Thrombocytosis has been associated with many tumor such as Hodgkin ’s lymphoma , non - Hodgkin ’s lymphoma , lung Crab , prostate cancer , pancreatic cancer , ovarian cancer , neoplasm of vesica and mesothelioma . In about 90 % of patients abide from reactive thrombocytosis due to a malignant disease have platelet level in the range of 400,000 - 1,000,000 per cubic millimeter .
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