What is Type 2 Long QT Syndrome?
The innate long QT syndrome occurred due to the variation in various factor responsible for for the regularization of ions in the heart . More specifically , the mutant may be in the ion channels which are creditworthy for move the ions in and out of the cell . eccentric 2 LQTS is the second most common form among various forms of farseeing QT syndrome . It is have by the variation in KCNH2 gene , which is also known as hERG . sealed medications are considered for deal this disease however , the fist option for oversee the disease is genus Beta - blockers . The other drugs which can be used for make out the condition is atomic number 20 - channel blocking agent . The variability in the genomic face may decide the symptoms in such patients . These patients may go on asymptomatic or they may have longsighted QT syndrome without syncope or cardiac arrest .
Symptoms of Long QT Syndrome
The symptom of the LQTS eccentric 2 bet upon the genetic expression of the mutate gene . There are sure instances when there are no symptoms of farsighted QT syndrome . Sometimes the expression is mild , and the patient may only notice prolonged QT interval . At fourth dimension there are the symptom of syncope and cardiac arrest . Thus , the symptoms may admit fainting , seizures like experimental condition and cardiac arrest that may be fateful . Further , the affected role with LQTS type 2 develop ventricular arrhythmia in response to cheap dissonance and stressful conditions . The symptoms are in general exacerbate in women in postpartum period .
Causes of Long QT Syndrome
The LQTS are divided into various typed depending upon the genes that gets mutated . The genetical farsighted QT syndrome is delimit as the LQTS develop due to the mutation of those genes , which are responsible for for maintaining the proper ion channel across the heart . The proper functioning of the ion duct is essential to provide the heart in right rhythm . The three most unwashed types of LQTS are type 1 , eccentric 2 and type 3 . eccentric 1 is caused due to mutation impact IKs potassium channel and type 3 is caused due to mutation in cistron feign sodium communication channel . LQTS case 2 is caused due to the mutation in KCNH2 or hERG gene , which is located on the chromosome 7 . KCNH2 encode the emf gated potassium distribution channel alpha - subunit Kv11.1 . These channel are all-important for rhythmic jiffy . Mutation in the gene causes in expiration in function and the deprivation may be sodding or fond depending upon the mutation .
Long QT Syndrome Treatment
The treatment approach in long QT syndrome type 2 is to prevent the patient role from sudden cardiac death . Those drugs should be avoided which may trigger the extend QT interval . Further , the discussion should also be such that it may prevent fainting , syncope or seizure . The drug which is the first choice in this precondition is beta blocker . But sometimes the drug fails to prevent the symptoms . The other drug course which can be used in long QT syndrome type 2 is atomic number 20 line blocking agent . Further the treatment with psychoactive agents is also considered . The psychotropic drugs which are used may be anti - depressants , neuroleptic agent , or anxiolytics . In certain stern example , the ICD are used . ICD is also acknowledge as implantable cardiac defibrillator . This machine is helpful in decline the calamitous cardiac arrhythmia .
Conclusion
Long QT syndrome character 2 is caused due to the mutation in KCNH2 cistron or hERG . The mutation lead in the abnormal ion transfer which lead in cardiac arrhythmia . The symptom may admit faint and seizures and the condition may exacerbate in gimcrack noise and conditions involving aroused tension . Further , the experimental condition is aggravated in women in post - partum stage . When the long QT syndrome is genetic , it is very unmanageable to supervise the symptom due to the reason that it is very difficult to guess the harshness and how much chromosomal mutation took place . The medication used to cope the long QT syndrome type 2 may let in beta blocker and atomic number 20 communication channel blockers .
Further , drug such as antidepressants and anxiolytics are also used to contend the conditions . In severe font , the implantable cardia defibrillator is used which corrects arrhythmia .
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