What is Lymphocytic Colitis?
Lymphocytic colitis is a uncommon GI status characterised by inveterate non bloody/ watery diarrhea due to rubor of the colon or the large intestine . The full term lymphocytic colitis was coined by Lazenby to differentiate the stipulation of other inflammatory bowel subject such as Crohn ’s disease and ulcerative inflammatory bowel disease . The condition was possibly named due to increased act of lymph cell in the affected tissue paper . The El Salvadoran colon commonly seem normal with flexible sigmoidoscopy or colonoscopy , but shows signs of ignition under microscopic examination . Since the colonic mucosa is not disrupted or ulcerous , chances of blood stain or pus tarnish BM is rarified .
Microscopic colitis is a terminus that is also used to describe lymphocytic colitis and another condition with alike signs and symptoms get it on as collagenic colitis . The symptom , symptomatic testing and direction of both these condition are same . Some trust lymphocytic inflammatory bowel disease and collagenous inflammatory bowel disease are part of the same term but at unlike phase . The microscopical difference between lymphocytic colitis and collagenic colitis are mention below :
Lymphocytic Colitis : This is characterised by increased number of white blood cells ( WBCs ) or lymphocytes in the colon tissue .
collagenic Colitis : This is characterised by presence of a thick layer of collagen ( a protein ) in the colon tissue .
Symptoms of Lymphocytic Colitis
Lymphocytic colitis is often suspected upon observe persistent unexplained diarrhoea without any blood or pus spark . The colon appears normal upon radiographic or endoscopic examination . The symptoms associated with this condition include :
Causes of Lymphocytic Colitis
Lymphocytic colitis is a rarefied stipulation and the accurate lawsuit of the condition is yet unsung . Researches are being carried out to screw more about this condition and figure out the causa of this unique experimental condition . However , based on notice , research worker believe the potential causes of Lymphocytic inflammatory bowel disease are as mentioned below :
Side Effects of Medications : inordinate intake of certain medicine can cause irritation in the facing of the Costa Rican colon go to inflammation .
Bacterial or Viral Infections : sure bacterium have the ability to produce toxins which may irritate the mucosal facing . Some viruses can also initiate inflammation .
Presence of other Auto Immune Conditions : machine immune condition is defined as a aesculapian condition where the consistency ’s resistant system attacks the normal sizable tissues of the consistence . Lymphocytic inflammatory bowel disease has been seen is close association with automobile immune conditions such asceliac diseaseorrheumatoid arthritis .
chemical reaction to Bile Acid : gall acid if not absorbed by the body , it may rag the Costa Rican colon lining .
Risk Factors with Lymphocytic Colitis
The risk factor associate with lymphocytic inflammatory bowel disease include :
Age and Gender of the Individual : It has been take note that lymphocytic inflammatory bowel disease is mutual between the age radical of 50 to 70 years . It touch women more than man . This is possibly due to hormonal change in cleaning woman Charles William Post climacteric .
Presence of Auto Immune Diseases : Lymphocytic inflammatory bowel disease is often associated with other underlying auto immune conditions such as rheumatoid arthritis , psoriasis , celiac disease , thyroid disease , character 1 diabetesetc .
Genetic Inheritance as a Risk Factor for Lymphocytic Colitis : The chances of assume lymphocytic colitis are more among multitude who has a family account of gastro - intestinal issues such asirritable intestine syndrome ( IBS ) .
Smoking : Studies have shown that there is a data link between smokers and developing lymphocytic colitis . This is more manifest among individuals with account of smoke between the age of 16 and 44 years .
Medications : As note earlier , intake of certain medications have adverse effect on the mucous membrane of the Costa Rican colon . These medication let in :
Diagnosis of Lymphocytic Colitis
The symptoms are often mistaken as other abdominal topic . If the symptoms do not improve within a few days , it is advise to consult a medical specialist for direction of the status . The condition is treat by a gastroenterologist . A detailed case history is obtained followed by physical scrutiny . limited aid is given to mention down history of medicinal drug , which may increase the chance of developing lymphocytic inflammatory bowel disease . A few tests are done to find out other condition such as celiac disease . Specific trial include biopsy of the colon tissue , which is obtained during colonoscopy or flexible sigmoidoscopy . These tests are done by inserting a long fragile subway into the colon through the rectal scuttle . The thin tube has a camera on its end to examine the inner portion of the colon ; and a tissue sample twist , to pull in tissue paper material for biopsy . Other tests let in stool sampling analysis and rip oeuvre , to look for secondary contagion and anaemia . Upper abdomen endoscopy with biopsy may be done to predominate out celiac disease .
Treatment and Management of Lymphocytic Colitis
In some cases , lymphocytic colitis may better on its own . However , in advanced cases , treatment may be necessary . The most common treatment modality includes :
Dietary Modification to Treat Lymphocytic Colitis : patient affected by this condition are advised to follow a lowly fat , depleted fibre diet . it’s advised to avoid dairy farm and gluten product and limit caffeine intake . Sugar intake should be decoct .
Lifestyle Modification to Manage Lymphocytic Colitis : Simple change in lifestyle such as equal hydration , keep off irritable solid food , including more of easily digestible solid food in dieting , eat little and frequent meals can avail in check the precondition .
medicine : In some case , the physician may prescribe medicine to ascertain the symptoms . These include anti diarrhoeal medications , medicament that blank out production of bile acids , anti - instigative drugs , medications for supressing resistant scheme etc .
discontinuance of medications that are surmise to increase the irritation .
operative Intervention for Lymphocytic Colitis : In uttermost cases , if the condition does not better with dietary modifications , modus vivendi modification or creation of new medicine , surgical process may be recommended to cover the condition .
Prognosis and Complications of Lymphocytic Colitis
The prognosis of lymphocytic inflammatory bowel disease once diagnosed is dependable . Most of the individuals are successfully deal without further complications .
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