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Juvenile myelomonocytic leukemia ( JMML ) , also roll in the hay as jejune continuing myelogenous leukaemia ( JCML ) , is a rare cancer of the rakehell that bear upon young fry under the eld of 4.1It hap when types of white blood line cells ( WBCs ) called monocytes and myelocytes do not mature ordinarily or when there is an uncontrollable growth of these two types of snowy blood cells . The unripened cells are known as blasts .
This rarified cancerous status can go on ad lib or be associated with other genetic disorder . harmonize to Cancer Research UK , it has been found that JMML occurs more or less more often in boys than in girls.2The Leukemia & Lymphoma Society estimates that around 50 children in the U.S. are diagnosed with JMML each yr , accounting for 1 % to 2 % of all childhood leukemia cases.3
Symptoms of Juvenile Myelomonocytic Leukemia
nestling with JMML may experience the keep abreast symptom :
Causes and Risk Factors for Juvenile Myelomonocytic Leukemia
The exact cause of most guinea pig of childhood leukaemia , including JMML , remains unreadable . However , some genetic disorder have been link up to an increase risk . For example , approximately 15 % of children with JMML have neurofibromatosis case 1.5Children with Noonan syndrome are also at an increased risk . Additionally , excessive alcohol wasting disease during maternity may promote the risk of the child originate leukemia .
Diagnosing Juvenile Myelomonocytic Leukemia
Diagnosis may involve a variety of psychometric test , admit :
Stages and Treatment of Juvenile Myelomonocytic Leukemia
While JMML does not have a standard staging system , the progression of the disease can be categorized into various phases such as untreated , remittance , minimum residuary disease , participating disease , recurrent disease , recalcitrant disease , and central nervous arrangement disease .
Treatment mainly revolves around root jail cell transplant , which is presently the only known cure for JMML . About one-half of the patient achieve tenacious - term remission with this treatment , although lapse are vernacular . Chemotherapy is also used , primarily to manage symptom and prepare for stem cell transplantation .
Conclusion
JMML is a rare but serious form of blood cancer affecting vernal children . former diagnosing and treatment are crucial for improving the prognosis . Stem cell transplantation offers a likely cure , highlight the grandness of timely aesculapian intervention .
