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What is Eosinophilic Granuloma?
Human body consists of Langerhans cells that are antigen presenting cells or accessary cells which take shape antigen complex at their cellular phone surface that are recognise by T- cells . These cells help in immune organisation of the body and are present in all the layers of epidermis . These mobile phone sense the presence of strange pathological bodies and communicate it to the immune cell of the body . They are notice in skin , vaginal lining , oral mucous membrane , and other tissues like lymph tissue paper . Eosinophilic granuloma is a rare , noncancerous type of Langerhans cell histiocytosis characterized by abnormal proliferation of these dendritic Langerhans cell that are derive from the bone marrow . These cells then migrate from skin to lymph nodes and may affect one individual bone and convert into multiple system upset . Eosinophilic granuloma occurs in both human and animals and is often referred as rodent ulceration because of the rule of the wound . Langerhans cell histiocytosis has three clinical variants namely : Eosinophilic granuloma ,
Letterer - Siwe disease and Hand - Schuller - Christian disease . Eosinophilic granuloma is a benignant version of Langerhans cell histiocytosis bear upon the child , teenager , and young population .
There are various type of Eosinophilic granuloma depending upon the natural event . These are :
Causes of Eosinophilic Granuloma
accurate cause of Eosinophilic granuloma is unknown , and the enquiry is in progress ; however , theories suggest the condition to occur because of some specific gene mutation . This gene mutation is somatic in nature and does not show transmitted inheritance .
Symptoms of Eosinophilic Granuloma
The symptom of eosinophilic granuloma admit :
Diagnosis of Eosinophilic Granuloma
Clinical manifestation and signs can assist in achieve the differential diagnosis .
Diagnosis of Eosinophilic granuloma is made byX- raysandCT scanof the region postulate .
ivory wound biopsy can be performed for more appropriate diagnosing of Eosinophilic granuloma . It is a process where a sample distribution of bone tissue paper is obtained under anesthesia by low incision and the sample is then sent to the labs . This helps in distinguish the benign and malignant tumors and eliminate the other possible differential diagnosing such asMultiple myeloma , Fibroma , Osteosarcoma , Osteomyelitis , Osteoblastoma , Rickets disease , Ewing ’ sarcoma etc .
Blood test present tense increase WBC- leukocytosis .
Prognosis of Eosinophilic Granuloma
Eosinophilic granuloma presents a good prognosis ; however , it may show ad-lib statistical regression . The condition is extremely radiosensitive .
Treatment for Eosinophilic Granuloma
Eosinophilic granuloma wound regress on its own within a period of two to three month ; however , it may take more than a year or two to conquer . Long stand lesion are painful and are treated with corticosteroid injection . Enlarged tumors may require surgical intervention for partial or complete removal .
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