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What is Calciphylaxis?
Calciphylaxis is a pathological condition in which there is abnormal Ca deposition in the body , which in the main affects the minor stock vessels and causes extensive skin wrong . This atomic number 20 deposition makes the blood vessels hard and hence Calciphylaxis is also bid as vascular calcification . Calciphylaxis affects the stemma vessels that supply rakehell to the subcutaneous fat and the skin . Calcium deposition can sometimes come about in the rake vessels of sure vital organs of the body , which may cause sure spirit imperil complication even though it is the skin that is primarily affected by Calciphylaxis .
This is a rare condition and is found mostly in people with remainder stagekidney disease , as in such vitrine the body is unable to wield normal level of various mineral include calcium . Calciphylaxis may also be at prison term related to atomic number 13 toxicity and vitamin D supplementation . If Calciphylaxis affects intragroup electronic organ of the body , then it can be catastrophic and in about 80 % of the cases the patient is not able to live due to Calciphylaxis .
What Causes Calciphylaxis?
As stated above , Calciphylaxis is caused due to unnatural calcium deposition in the blood watercraft which supply blood to the subcutaneous blubber and the skin . This condition is mostly found in mass with kidney diseases who have abnormal calcium level , but there are some cases of Calciphylaxis in mass who have normal calcium levels and do not have any kidney dysfunction .
Calciphylaxis Caused Due to Kidney Failure : This is the main cause of Calciphylaxis . One of the function of the kidney is to regulate and curb the levels of dissimilar mineral in the body which includes calcium . If an individual has a dysfunctional kidney , then the kidney is not capable to regulate or see the levels of these minerals in the organic structure let in atomic number 20 and there is an increase in the level of atomic number 20 in the body . These calcium deposits gradually start to accumulate on the line vessels , which then slowly become calcified . This calcification over clock time leads to Calciphylaxis .
Some of the Other Less Common Causes of Calciphylaxis are :
What are the Symptoms of Calciphylaxis?
The main presenting feature film or symptom of Calciphylaxis is the developing of peel stain leading to slough and ulcers . The lesions because of Calciphylaxis are fundamentally seen in the abdomen , thighs , buttocks , low-spirited part of the ramification and groundwork withitching , pain , and burning sense datum in the affected area . During the former level of the disease when there is development of the lesions , there will be cloud of the skin and the tegument will have a violet discoloration .
There will also be bleeding with blood filledblisters . Once the disease condition advance , the development of the lesions advancement and they take a star shaped appearance with a black center . These lesions become very unfaltering and are tender to palpation . In the advanced stages of Calciphylaxis , there is a formation of gangrene and multiple deep ulcer on the touched area .
How is Calciphylaxis Diagnosed?
The lesions formed from Calciphylaxis are quite like to those form by other vascular condition and hence it is vital to rule out other vascular conditions causing the symptoms . Once other conditions have been ruled out , then the symptoms may point towards Calciphylaxis and investigating for that is started . Some of the tests done for affirm the diagnosis of Calciphylaxis are :
Blood tests to check for the story of calcium in the physical structure along with the levels of P , creatinine and PTH levels . A sheer disco biscuit - ray of the moved area may be taken to wait at the extent to which there is damage done to the tegument . A skin biopsy may also be done for confirmation of the diagnosis of Calciphylaxis .
How is Calciphylaxis Treated?
The discussion for Calciphylaxis reckon on the severity of the condition and the extent to which the blood vessels are calcified . If the disease has progressed to gangrene and ulcers , then the patient will be station to scent care specialiser to prevent the transmission from spreading to the head of septicemia which is a life threaten condition . The affected role will be treat with antibiotic drug and any necrotic tissue will be debrided . Another priority for the physicians is to restore normal blood and oxygen supply to the areas where tissue gangrene has not taken berth because of lack of blood and atomic number 8 .
Hyperbaric O therapy is one such elbow room to prevent any tissue affected due to Calciphylaxis . For coagulation issues , clot dissolving medications will be given so as to restore blood flow to the stirred area . Apart from this , for treat Calciphylaxis as a disease the focal point is on reducing the atomic number 20 and phosphate levels . This may be done by mode of dietary provision with foods that are low on calcium and phosphate . There are certain medications which are design to slim down calcium stratum in the soundbox . These medicine are :
It is important that Calciphylaxis be treated in a timely manner so as to melt off the chances of complications . Some of the complicatedness of Calciphylaxis are :
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