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What is Kuru?
Kuru is a fatal and rare disease of the queasy system , which occurred primarily during the fifties and 1960s among a kin group have sex as the Fore citizenry in the upland of New Guinea(1 ) . These Fore people got this disease through the act of cannibalism on stiff of their relation when performing the last funeral rites.(1 )
Kuru is a soma of spongiform encephalopathy,(2)which is a family of diseases characterise by degeneration of brain tissue paper and the healthy tissue gets replaced with clump of cysts give the psyche of the affected role an appearance of parazoan .
The symptoms of this disease consist of loss of coordination , muscle vellication , involuntary movement , dementedness , trouble inwalking , difficulty in feeding , mood and behavioral changes.(1)Difficulty in deplete causesmalnutrition .
What Does Kuru Mean?
The meaning of kuru is “ tremble or shivering . ”(1 )
What are the Causes of Kuru?
Kuru belongs to a group of diseases called prion disease also known as familial spongiform encephalopathies ( TSEs).(3)The cerebellum is in the main sham in this disease which is a part of the brain which is creditworthy for balance and coordination .
Kuru is not make by viruses , bacterium , or fungus kingdom . Prions are the unnatural and infectious proteins which induce kuru . Prions do not procreate as they are not living organisms . They are misshapen , pulseless proteins , which can multiply in the brain resulting in clumps that intervene with the normal mind process .
Some of the other degenerative diseases make by prions are Gerstmann - Sträussler - Scheinker , Creutzfeldt - Jakob , disease and fatal familialinsomnia . Kuru and these spongiform disease make holes which front like sponge in the head and this is lifetime threatening .
Is There Any Cure For Kuru?
There is no known cure for Kuru and this disease is often fatal within a year of contracting it.(4 )
What Are The Symptoms Of Kuru?
Symptoms of Kuru resemble some of the more well knownneurological disorders , such asstrokeorParkinson ’s diseaseand these are : poor coordination ; difficultness walking ; difficulty swallow ; dementia;slurred speech;muscle tremorsandtwitching ; behavioural change ; moodiness ; unfitness to hold objective and random , driven cry or laughing.(1 )
What are the Stages of Kuru?
This disease is ordinarily preceded byjoint painandheadaches . As these are uncouth symptom , they are often dismissed as sign that there is a more serious disease occur in the body . There are three stages in which Kuru occurs:(4 )
First Stage of Kuru : In this stage , there is some expiration of corporeal control condition and the patient role has difficulty in maintaining posture and balancing .
2d stagecoach of Kuru : This is also known as the sedentary microscope stage , as the patient is not able to walk . There are also significant nonvoluntary jerks and motion along with physical structure tremors .
Third Stage of Kuru : This last stage of the disease see the patient being sick-abed and incontinent . The patient also is ineffectual to talk and can also exhibit signs of dementedness or have demeanor changes which make them look as if they do not manage about their wellness . Malnutrition and starvation is seen in this third stage and this occurs due to the affected role experiencing difficulty in eating and swallowing . All these secondary symptom can induce death of the affected role within a year . Many patients die from pneumonia in the end .
Contraction of Kuru
Kuru is constrict by consuming an septic brain or hail into contact with open sores or wound of a person give birth it . Kuru was seen mainly in a clan of the great unwashed experience as the Fore people of New Guinea where they squander brain of beat relatives during funeral rituals.(6)Children and women were primarily infected as they were the chief participants in these rites .
This practice session of cannibalism has been discouraged by the New Guinea government . However , there are still subject seen due to the tenacious brooding full point of this disease , however it is rare .
How is the Diagnosis of Kuru Made?
The doctor performs a neurological test on the patient , which also includes neurological office , aesculapian story , blood line test ( folic acid level , thyroid gland ) and kidney and liver role trial run are also done to shut other causes of the symptoms .
Electro - diagnostic run , such as electroencephalogram ( EEG ) are also done to tax the electrical action in the brain of the patient . MRI scancan also be done ; however , it can not help with classic diagnosing .
How is Kuru Treated?
As of now , there is no known successful treatment for Kuru . The cause of this disease , which are prion , is very difficult to demolish . Brains that have prion go on to remain infective even when they are preserved in formaldehyde for many days . The intervention of kuru consist of supportive therapies , such as pain in the neck killer whale for managing pain and physical therapy to help with bowel movement and mobility .
How Can Kuru Be Prevented?
This is an exceptionally rarefied disease and can be contracted by eating septic brain tissue paper or when coming in cutaneous senses with sores that have kuru prion . Government has discourage this pattern of cannibalism to forestall this disease .
allot to NINDS , kuru has almost completely disappeared.(5 )
The incubation stop of Kuru can be quite drawn-out as much as 30 years . There have been case report many age after this cannibalism practice session has stopped .
Kuru is rarely diagnose these days . Symptoms resemble those of Kuru can be a sign of another acute spongiform disease or neurologic disorder .
What is the Prognosis For Kuru?
The forecast of this disease is poor with death being the death . Patients suffering from Kuru need assistance or service with go , standing and tardily lose the power to eat and get down because of these symptom .
Kuru has no cure and the patient can get into a comatoseness about six to 12 month after receive the initial symptoms . This is a life endanger disease and can be prevented by avoiding exposure .
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