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Introduction:
Enzymes are the most important part of the metabolic process and have the capability to increase the metabolic process . enzyme are molecules that interact with the substratum to mould an enzyme - substrate composite and then convert them into products . Enzyme - based therapeutics ( think of the utilization of enzymes to care for diseases ) are gaining more and more attending due to their selectivity , efficiency , and safety visibility . Various enzyme - found treatments are available the right way now such as the enjoyment of chymotrypsin , papain , bromelain , and serratiopeptidase for several condition .
Defining The Enzyme Serrapeptase:
Among all these enzyme - establish treatments useable , in this clause , we are discussing the use of serrapeptase in the intervention of Lyme disease . Serrapeptase which is also screw as serratiopeptidase is first used in Japan in the twelvemonth sixties for its anti - inflammatory properties . Later , its other attribute such as fibrinolytic ( excite the dissolution ofblood coagulum ) , and analgesic property were studied by various scientist . It has a wide ambit of safety profiles and is used in a form of condition such as surgery , orthopedics , gynaecology , and also dentistry .
Serrapeptase is an enzyme that is incur from the Serratia marcescens ( present in the gut of silkworms ) . The specialty of this enzyme is that it is a proteolytic enzyme that converts protein into its little subunit which are known asamino acids . It only breaks the non - living protein inside the body that is formed only in the unnatural condition such as inflammation and pain .
How Does Serrapeptase Work?
Serrapeptase and all other proteolytic enzyme breaks down the proteins through the process of hydrolysis . They add water or hydrolyse some specific bond that are present between different aminic acids which result in the breaking of proteins into amino acids .
Role of Serrapeptase in the Diagnosis of Lyme Disease
What is Lyme ? – Lyme diseaseis one of the most common vector - borne diseases that affects over 300,000 Americans per year and at least 2 million individuals have been reckon to suffer from post - treatment Lyme disease syndrome ( PTLDS).[1]It is triggered by the bacteria Borrelia mayonii . It is transferred to humans through the bite of infected ticks . Ticks are known to convey a blanket mountain range of bacteria , virus , and parasites . Based on the information that is give by the World wellness brass ( WHO ) Lyme and other tick - suffer disease can induce a significant impact on human health and finding a proper intervention for these is the major challenge right now.[1 ]
Symptoms of Lyme – The major symptom found in the character of patient lose from Lyme arefatigue , headache , and a distinctive cutis efflorescence call erythema migrans . If the infection remain untreated it can also spread to marijuana cigarette , the heart , and the nervous system.[2 ]
Diagnosis of Lyme – The diagnosis of Lyme disease is done by using some serology tests such as an ELISA mental testing followed by a Western smear test . However , current serology test demonstrate a broad sensitivity ranging from 34 % to 70.5 % leaving many septic patients with false negative testing . So , to get the best this limitation option technique such as polymerase chain reaction ( PCR ) are used to diagnose the Lyme .
Role Of Serrapeptase In The Diagnosis Of Lyme:
Normal PCR testing show up very less exact test results but when certain biofilm busters such as serrapeptase are used , it could lead to bacterial parentage outlet , thus increasing the spirochete load , make PCR prove more sensitive and in this way , serrapeptase makes the diagnosis more accurate . If the diagnosis is done correctly , then the unspoilt treatment can be provided using serrapeptase and many other drug such as dapsone.[3 ]
Treatment of Lyme Using Serrapeptase:
In the fount of Lyme , sometimes , biofilm - corresponding aggregates are forge allowing causative bacteria to be resistant to adverse environmental conditions.[4 ] One of the main attribute of biofilms is that they are highly resistant to adaptive and innate immune system as well as great leeway to antibiotic and antibacterial federal agent . Due to the presence of these biofilms , the antibiotic treatment failed to treat bacterial transmission . There are various strategies to inhibit biofilm formation , one of which is the use of an anti - biofilm agent . Many proteolytic enzyme enzymes are hypothesized to be a potential treatment of biofilms . In proteinase enzyme , metalloprotease is diddle a very primal role .
Serratiopeptidase ( anti - biofilm agent ) is a commercially usable metalloprotease that has leaven to be very effective against a smorgasbord of biofilm - associated aesculapian conditions .
The Mechanism Behind Serrapeptase Action As An Anti-Biofilm Agent:
There are various slipway in which serrapeptase affects the establishment of biofilm agents . It can modify the virulent phenotype of bacterium in biofilms , and modification of phenotype will head to decreased power against environmental element and hence its formation is decrease . It also enhance the bactericidal personal effects of antibiotics against biofilms .
In the treatment of Lyme disease , various antibiotic drug are used and there is very little grounds that serrapeptase is being used as an adjuvant therapy of antibiotic to increase the antibiotic activity . However , there are only two low - caliber studies or clinical trials exhibit which support this statement.[5 ]
Conclusion:
Serrapeptase is an enzyme that is suffer anti - inflammatory , fibrinolytic as well as analgesic natural process . However , the consumption of serrapeptase in the treatment of Lyme disease is not well known and there is no grounds that confirms that serrapeptase is good in Lyme and other tick - borne disease . However , very trivial evidence is present that it is used as adjuvant therapy with antibiotic drug and increases antibiotic natural process . There is a demand for more clinical research that confirms the role of serrapeptase in the handling of Lyme disease .
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