Is It OK To Take 1000 mcg of Vitamin B12 a Day?
The day-to-day dosage of 1 mg ( 1000 mcg ) oral vitamin B12 has shown ripe farseeing - terminal figure resolution ; the possible action of intermittent maintenance rule of thumb is investigated . Vitamin B12 or cobalamin plays a central role as a coenzyme in DNA synthesis and cadre suppuration , as well as in the synthesis of neural lipids . The human organism is not able-bodied to synthesize it and must obtain it from the diet , mainly from food for thought of animal origin ( meat , Milk River and first derivative , eggs , Pisces the Fishes ) .
The vitamin consume in the dieting is separated from animal proteins by pepsin and gastric hydrochloric Elvis , connect haptocorrin , a protein of salivary origin , which is dissociated in the duodenum by the action at law of pancreatic peptidase . It is absorbed in the distal ileum , after passing through the small intestine linked to the intrinsical gene ( IF ) , a protein synthesise in the parietal cell of the gastric fundus . The B12 - FI complex binds to the ileal cell sense organ and is absorbed by endocytosis . Vitamin B12 surpass into the blood stream bound to transcobalamin II , which transports it to the liver and other field of the body .
It is significant to note that , apart from this mechanism , between 1 and 2 % of the B12 ingested is absorbed by passive diffusion , regardless of the IF , of the unity of the distal ileum or of the existence of gastric revision or selective malabsorption of cobalamin .
More than 75 % of the cobalamin egest by bile is reabsorbed . Its urinary elimination is usually low .
The daily requirements of vitamin B12 are around 2 to 2.5 μg , provided in a balanced diet . The tissue computer storage of B12 are wide , between 3 and 10 mg , and can take decades to empty .
B12 Deficiency Causes
The chief effort of vitamin B12 deficiency can be divided into three groups : depressed exogenous intake , wretched digestion and malabsorption of the vitamin . The first come about in rigid vegetarian .
The pathologies most frequently associated with inadequate digestion of B12 are atrophic gastritis ( relate or not to Helicobacter pylori ) , achlorhydria and gastrectomy . Regarding the causal agent of malabsorption , it is worth mentioning pernicious anemia , a classic example of megaloblastic anemia , in which the parietal cell are put down by autoantibodies , bring about an IF deficiency that lead to insufficient absorption of cobalamin . The resection of the ileum or ileal diseases may also stimulate malabsorption .
Treatment For Vitamin B12 Deficiency
The administration of vitamin B12 to objurgate or prevent the deficiency is commonly for life , and has traditionally been order in the class of intramuscular shot . The most common regime consists of daily doses of 1,000 μg for one week , followed by hebdomadal injectant for 4 workweek and , then , monthly . This treatment does not usually give rise adverse outcome , but it need double sojourn , discomfort and risks in relation to the use of the parenteral route .
There is abundant accumulated evidence that the replenishment of B12 can be carry out efficaciously orally . Several report have shown that the small percentage ( 1 - 2 % ) of vitamin that is passively absorbed in the bowel could be sufficient to attain , with mellow doses of vitamin B12 , adequate concentration in the body , even in slip of absence seizure of IF by pernicious anemia or gastrectomy , achlorhydria , malabsorption or lack of integrity of the final ileum . Thus , if the day-to-day needs of B12 are approximately 2 μg , distribute oral postscript at high doses ( 1 - 2 mg ) once a day can achieve a sufficient amount to ascertain the note value and filling of the tissue storage through passive enteral absorption . Adverse effect to overdosage of vitamin B12 have not been reported . The unwritten handling avoids the tortuousness integral to the shot and also proportional contraindications , such as anticoagulation . It is only contraindicated in patients with unfitness to take unwritten medication or who presentvomitingordiarrhea .
Conclusion
As with any other medication , it is necessary to check the adherence of the patient role , purportedly more uncertain than with the monthly visits for the judicature of the injectable .
Also interpret :
