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About Arthrogryposis:
Arthrogryposis , which is also known by the name of Arthrogryposis Multiplex Congenital , is a pathological term characterized by multiple joint contractures and muscle helplessness throughout the body at the time of the birth of the tike . Arthrogryposis is a symptom more than a circumstance and hence an underlying campaign for it has to be identified .
Amyoplasia is the most coarse form of Arthrogryposis which is characterise by contractures of the hands , wrists , elbows , berm , articulatio coxae , feet and knee , although the severe form of Arthrogryposis can do contractures in every joint in the soundbox , including the jaw and the spinal cord .
There is no single cause for the development of Arthrogryposis , although study suggest that fetalakinesiaplays a full of life role in a tike developing Arthrogryposis . During foetal development it is normal for the foetus to have normal joint movement and exploitation during the former form of gestation . Problems occur when there is a lack of fetal movement during the developing form of the fetus which result in extra connective tissue paper to develop get an firm and blind drunk joint which at last result in the developing of Arthrogryposis . The longer is the duration of immobility of the joint , the severe will be Arthrogryposis .
Is Arthrogryposis Genetic?
The answer to this question is , Yes , Arthrogryposis is a congenital disorder . study have proven that Arthrogryposis can be cause by mutations in at least two genes which are TPM2 and MYBPC1 . These genes are combat-ready in the muscle cells and interact with the muscularity proteins to ease muscularity contraction .
However , these studies do not give a absolved cause as to how mutations in the above mentioned cistron can result in the developing of joint contracture which are the characteristic feature of Arthrogryposis . investigator however consider that these contracture are come to to problem with sinew muscle contraction which limit the mobility of the joint and result in contractures realize in a condition like Arthrogryposis .
Arthrogryposis is inherit in an autosomal prevailing pattern mean that one copy of the defective gene from either parent is good enough for the development of Arthrogryposis . In most of the grammatical case , a child with this stipulation will have a parent or a direct relative or sibling with Arthrogryposis .
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