Alpha thalassemia is of different character and asperity is relative to the numeral of genes that have become abnormal . The severity ranges form alpha thalassemia minima to alpha thalassemia major , the latter being the most severe and have life threatening outcome .
Is Alpha Thalassemia Life Threatening?
Life-Threatening Complications
The severity of the alpha thalassemia disease count upon the number of factor that gets mutated . More the figure of gene mutation more severe the disease and more unmanageable it is to oversee the symptoms . The alpha thalassemia can be divide in to following type :
Thus , the life expectancy and the life threaten consequences depend upon the severity of the disease and the number of genes that gets mutate . Also , more severe the disease , more it is difficult to supervise . The standard therapy for the grave build of disease is frequent blood transfusion which has its own complications .
Alpha Thalassemia
Hemoglobin is pen of four fractional monetary unit of globin . Two units of alpha globin and two fractional monetary unit of beta globin is present . All the four unit are essential for the synthesis of normal hemoglobin . Thalassemia is caused when the cistron regulations the aspect of the synthesis of globin gets mutated . If the cistron of alpha globin are mutated , the condition is called alpha thalassemia and if the factor evince the genus Beta haematohiston are mutate , the condition is known as beta thalassemia . The consideration is inherited in autosomal recessive pattern which means that both the allele should be mutated to manifest the symptom of the disease . Alpha haematohiston is expressed by four gene which are present on chromosome 16 in two pairs . Thus , the severity of the disease depends upon the number of gene that gets mutated . The cistron ask in the expression of alpha globin are HBA1 and HBA2 .
Conclusion
Alpha thalassemia John Major occurs due to mutation in all the genes which are expressing the synthesis of alpha hematohiston . It is the most severe eccentric of alpha Mediterranean anaemia and may have life-time threatening consequences .
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