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Darier disease ( DAR/ Darier disease/ Dyskeratosis Follicularis / Darier – White disease/ Keratosis follicularis ) is a rare , often chronic , genetic disordercharacterized primarily by non - contagiousskinchanges . Darier disease or Keratosis Follicularis is an autosomal disorder , meaning that a exclusive gene inherit from one parent causes this disease . LikeHailey - Hailey disease , Darier Disease is also group as a hereditary acantholytic dermatosis . peel change commonly start in adolescence . Flare - ups of Darier Disease or Keratosis Follicularis are triggered by tight - fit clothes , humidity , strain and sun exposure . Darier disease feign both men and women evenly and is not communicable .
Majority of the patients develop symptom of Darier Disease or Keratosis Follicularis before the age of 30 . Many patients can also have this disease in a mild build of which they are not aware of . Individuals with knockout Darier Disease have chronic relapsing - remitting symptom . In some patient role , the symptom may resolve spontaneously . The rashes or lesions of Darier Disease or Keratosis Follicularis worsen upon exposure to sun and sometimes bycorticosteroiduse . Patients with Darier Disease or Keratosis Follicularis can have flare ups of this condition with bacterial infections . Patient ’s overall health unremarkably will be dependable irrespective of the severity of this shape .
discourse of Darier Disease or Keratosis Follicularis comprises of topical antibiotics and retinoids , unwritten antibiotics and retinoids , antiviral medications , use of sun blocker and moisturizers .
Causes of Darier Disease or Keratosis Follicularis
As refer antecedently , Darier Disease or Keratosis Follicularis is a genetic disorder and is choke on in an autosomal dominant fashion . The defective factor which stimulate this disease is present on an somatic chromosome and a single defective gene from one parent is enough to cause this condition . However , not all the patients deliver this unnatural cistron will have symptoms .
variation in the ATP2A2 gene cause Darier Disease or Keratosis Follicularis and this factor is present on chromosome 12q23 - 24.1 . The exact method acting of how this unnatural gene causes Darier Disease or Keratosis Follicularis is not clear and is still under research .
Signs & Symptoms of Darier Disease or Keratosis Follicularis
Different individuals have dissimilar symptoms of deviate degrees . Some have very balmy symptoms , some have severe and some patient have very elusive symptoms which they do not acknowledge at all . The follow are the characteristic of Darier Disease or Keratosis Follicularis :
Investigations for Darier Disease or Keratosis Follicularis
Darier Disease or Keratosis Follicularis is normally diagnosed upon physical examination and with family story ; however , it can be flurry for other hide problems also . For this ground , hide biopsy can be done to confirm the diagnosing .
Treatment of Darier Disease or Keratosis Follicularis
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