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Craniopharyngioma is a uncommon character ofcancer . It is a primarybrain tumorwhich is benign and later may become malignant . It mainly affects children and is now and then observed in adults . Craniopharyngioma is of great concern since it ’s a childhood genus Cancer .
What is Craniopharyngioma?
Craniopharyngioma is a tumour that occurs near the pituitary secretory organ and the hypothalamus region of the nous . It is present in the strain of a large cyst or multiple vesicle fill with turbid , proteinaceous and yellow coloured fluid . by and large , Craniopharyngioma is a localized benign tumour . However , it may become large , malignant and can spread in an anterior , posterior and sidelong style to different region of the psyche . Presence of tumor affect the functions of the brain . Although treatment facility are available , it is difficult to treat Craniopharyngioma due to the location .
Craniopharyngioma occurs in both kid of years 5 - 14 year and in adults of eld 65 - 75 age . Craniopharyngioma found in children is of type Adamatinomatus and is not a solid neoplasm . While in display case of adult , it occurs as a papillose type ( solid tumour ) . Due to the departure in types of tumor , the discussion in both case varies .
Symptoms of Craniopharyngioma
Craniopharyngiomas pretend part of the mental capacity and due to their comportment there is also an increase in the intracranial insistency . These tumors interfere with the endocrine yield , growth and visual sense . The effects are manifest in form of symptoms as :
Epidemiology of Craniopharyngioma
Prognosis of Craniopharyngioma
Generally the prognosis of Craniopharyngioma count on the size , type and location of the tumor in the brain . It is follow that after operative treatment , the rate of recurrence for both benign and malignant ( rare ) craniopharyngiomas is very high-pitched . Overall , it shows poor prognosis .
During diagnosing , the overall 2 year survival rate for a patient role is 86 % and 5 years endurance rate is 80 % . This rate varies by age group as good prognosis ( 5 year survival of the fittest rate is 99 % ) has been observed in case of children and patients below 20 years of years . While , in vitrine of the older patients i.e. , above 65 old age , an overall miserable prospect ( 38 % at 5 years ) was observed .
Causes & Risk Factors of Craniopharyngioma
Like many other cancers , the cause of craniopharyngioma and its risk factors is not acknowledge .
Pathophysiology of Craniopharyngioma
There is still modified knowledge on the genetic basis of this neoplasm . Although , there is red of tumour suppressor gene , activation of oncogenes , which deal place in craniopharyngiomas too , however , the specific familial detail still stay subtle . Some research sketch have shown that beta - catenin and Want pathway may have a significant role in the pathogenesis of these tumors . The accurate mechanisms underlying pathogenesis ask to be elucidated .
Complications of Craniopharyngioma
Diagnosis of Craniopharyngioma
The diagnosis of Craniopharyngioma involves :
Treatment of Craniopharyngioma
The discussion for nestling with craniopharyngioma should be design by a team of health caution providers , sooner an inter - disciplinary team who are expert in deal children with learning ability tumors . Various type of treatments used for address craniopharyngioma in youngster are :
Craniopharyngioma is a rare cancer and mainly affects tike . For beneficial handling outcomes , it should be treated at a centre with many long time of experience in treating the patients . The cause and underlying molecular pathogenesis of this Crab needs to be elucidated to enable better intervention direction in the future .
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