The full term “ asthenia ” derived from the Greek , means absence of strength or vigor . It is a complex symptom that at the same time encompasses the strong-arm and the psychic in a global agency , is subjective and involves a set of vague esthesis , dissimilar for each someone which is perceived and expressed through the anxious and the muscular system . From the physiological gunpoint of thought , you could consider fatigue duty as the tiredness that occurs after the efforts , and asthenia as the same aesthesis , but without efforts to justify it .
In the asthenia , you may identify three different components that participate in a unlike score grant to the case : 1 ) indolence , faintheartedness , deficiency of vim and the demand to rest before tasks that did not produced them previously ; 2 ) generalized helplessness : anticipate sense of difficultness in start and maintain an activity ; and 3 ) mental fatigue duty : qualify by adapted concentration , memory loss and emotional lability .
Although fatigue is a common reason for consultation as a undivided symptom , it sometimes appears as a constituent of a clear subjacent disease .
It is not infrequent that it is a symptom , ailment or complaint repeated over fourth dimension , in different consultations , with the same or different professional and , in general , without the doctor ’s response .
Fatiguemay be normal when an intense feat is made , but when it is not related to the performed behaviour , it is called “ pathological ” fatigue .
It is a symptom that can occur during the period of convalescence of different disease and surgeries . All masses have experience the spirit of astheny , for example during viral infections . In these cases , the obvious human relationship with a disease of clear diagnosis makes the asthenia is not , by itself , a drive for concern . Very different is the situation in which the astheny dominate the clinical presentation and compromise the usual bodily function , enclose the threat of potentially serious disease .
Can Vitamin B12 Deficiency Make You Tired?
Vitamin B12 deficiency is manifested clinically by general symptoms such as helplessness , pallor , and megaloblastic macrocytic anaemia , also GI symptoms such asnausea , disgorgement , severeanorexia , glossitis , diarrheaand malabsorption of nutrients and for neurologic symptom among , which paresthesias in the limbs are highlighted , incoordination and loss of vibratory sensitivity . This insufficiency is practically non - existent in humans by poor ingestion ( except perhaps for strict vegetarians ) because most solid food are productive in vitamin B12 and the day-to-day prerequisite is very low ( about 1 ug for 24 hr ) . Therefore , it is clear to conclude that this lack is always lower-ranking to a variety of nonspecific entities or to some specific genetic disorders .
Once the vitamin reaches the stomach it is combined with a mucoprotein secreted by the parietal prison cell holler “ intrinsical factor . ” The complex intrinsic factor - vitamin B12 is then formed , which upon arriver at the ileum is capture by particular receptor subsist there . afterward , it is turn into the portal circulation where it is take up by the transcobalamin II globulin responsible for transporting it to the liver .
pestilent anemia(prototype of vitamin B12 insufficiency ) is a specific disorder due to the absence of parietal cells of the stomachal mucosa that are responsible for producing the intrinsic factor , essential for the absorption of the vitamin . Other nonspecific gastrointestinal hoo-ha may produce the same upshot , such as the decrease or absence of iatrogenic parietal cell ( gastrectomy ) , the change of the ileal mucous membrane , the absorption web site of vitamin B12 ( tropical sprue , enteropathy gluten , resection of the last ileum ) , of the presence of plant life or parasites that vie with the host in the use of the vitamin ( blind loop syndrome , diverticulosis , diphilobotrium latum plague ) , or pancreatic - inveterate disease , in which case the pathophysiology of malabsorption of vitamin B12 is not well known .
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