Can Vitamin B12 Be Taken On An Empty Stomach?

Vitamin B12 is best convey on an empty stomach . It is better to nullify assume B-12 with certain foods . intellectual nourishment may interfere with B-12 absorption , leading to the ingestion of a much smaller measure of the overall dose . Other vitamin are best taken with food for thought , for example , vitamin degree centigrade which on empty abdomen cause sickness or battery-acid sensitivity . Among vitamins , B-12 is an exceptional one .

How Is Vitamin B12 Absorbed In An Empty Stomach?

In intellectual nourishment mathematical product like animate being meat , vitamin B-12 broadly exist with protein . When it reaches the stomach , pepsin and acrid pH breaks these proteins and release B-12 in devoid form . This free B-12 again binds to haptocorrin R - protein , which is secrete by salivary glands and parietal cells in the stomach . In the duodenum , the less pH cause the pancreatic proteases to degrade the haptocorrin -vitamin B12 complex and release . It again adhere tightly to intrinsic factor raise by parietal cells .

In the mucosal cells of the distal ileum , the vitamin B12 - Intrinsic Factor complex is recognized by special receptors . Vitamin B12 then enters the blood bound to another binding protein , transcobalamin , the complex is known as holo - transcobalamin . The bulk of vitamin B12 in bloodline is attach to haptocorrin and only a minor dimension is bound to transcobalamin . Holotranscobalamin is the biologically active fraction of vitamin B12 in the rip as it is in only this course that vitamin B12 is deliver to all the cellular phone of the body . Vitamin B12 soak up in the intestine subsequently gets transfer to the liver via the portal system . There is extended enterohepatic circulation of vitamin B12 and B12 is transported from the liver , via the gall duct , to the duodenum .

Can Vitamin B12 High Dose Kills?

According to some research involve too much vitamin B-12 can pass to side effect . It enounce that high dose of B12 may reduce the effectiveness of certain antibiotics , for instance , tetracycline , a drug used to deal respiratory , urinary tractand skin infection . However , there is no potential evidence or resource about the deleterious force of an overdose of B-12 . Because B-12 is a water - soluble vitamin and it is excreted in the weewee when consumed in surfeit , it ’s difficult to overdose on this essential nutrient .

Vitamin B12 Drug Interactions

Numerous drugs , such as anticonvulsants , diabetesmedications , venter acid reducers and chemotherapy drugs may deplete vitamin B12 levels in your body . The University of Maryland Medical Center says the following medications may interact with B12 in your body :

Possible Side Effects of Vitamin B12 Tablets

It is always necessary to learn with physicians first , particularly if deficient patient have certain pre - existing wellness conditions like Leber ’s disease before taking B12 addendum of any kind . In sound soul , redundant vitamin B12 in all probability wo n’t cause problems . However , the written report say if substandard patients have eye disease like Leber ’s disease , B12 supplements can seriously damage the visual nerve .