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Treatment and direction for patients with Reye ’s syndrome required prompt hospitalization in intensive care social unit . Regrettably , there are no sure drug available for an effective cure for Reye ’s syndrome within a short period of time . The treatment is usually targeted to lessen the personal effects affiliate with metabolic dysfunctions and cerebral edema . There is no specific treatment for mitochondrial damage and it is still in experimental stage . Continuous monitoring neurological , respiratory , cardiovascular , coagulative , and electrolyte counterpoise are necessary for patients . science laboratory test results recognition and treatment is the most reasonable method acting . Successful management and care at initial stage will certainly trim the neurological symptom and fatality rate rate .
youthful tike directly ( within 36 60 minutes ) 1500 to 1800 ml of 5 % or 10 % dextrose , mannitol , glycerol , or desametasone is administered intravenously per day . The temperature should be keep below 37 ° C with a cool cover . Hypertonic endovenous glucose shot may obviate the growing of the syndrome specifically brain swellings . Quantitative blood serum glucose determination should be performed every four hours . Serum osmolality should be measured every four minute and kept below 320 mOsm per liter . Vitamin K disposal determine to be useful in restoration of prothrombin time to normal . In some cases , a transfusion might be all important if there has been major rip loss . Hemodialysis ( Peritoneal dialysis ) is recommended used to absent toxins i.e. , think to be partly responsible for for the nous swelling .
Can Reye’s Syndrome Be Cured?
There is no therapeutic for reye ’s syndrome . The main objective of the treatment is to assure intracranial pressure i.e. , extradural , subarachnoid and ventricular spaces are supervise continuously . The intellectual perfusion pressure must be more than 50 mmHg to void tissue ischaemia . Intracranial pressure level above 20 mm Hg should be reduced with endovenous mannitol . The patient role is put on a gas helmet with ensure hyperventilation and substantiate carbon dioxide tension at the appropriate level is essential . key venous and arterial pressures must be monitored . paralyse the patient with an broker such as pancuronium commonplace help to control intracranial press . In some case , the high-pitched doses of corticosteroids are order , but then no benefits have been mark in treating patient even in high does . In recent times , high - dose barbiturate therapy ( pentobarbital , 3 to 5 mg per kg BW ) has been suggested as a therapeutic approaching to several types of acute brain accidental injury , let in Reye ’s syndrome .
Medications are available to care for the high floor of blood serum ammonia and free roly-poly acids . Neomycin enemas are used to decrease the hyper ammonia floor in the blood . However , wretched prospect is identified . Prognosis is good , only if quick treatment give in clock time for the hospitalized patients . This will reduce 90 % of the deathrate and patients who admitted at the last stage of the diseases could cause 80 to 90 % mortality . Death case happen as there is no sign or incendiary response . It is peculiarly observe in some late phase patient , which results from kidney and cardiac failure . sure non - steroidal anti - inflammatory drugs prescription drug such as diclofenac and mephenamic acid are must be stopped as they worsen the cases .
The example of the Reye ’s syndrome was more than 1000 during the 1980s , but at present one or two incidence occurs rarely in different region of the world . So much research studies are n’t concenter on Reye ’s in the present era . Hence , till now there is no precise explanation given on induction mechanics and incidence of the disease and how some eccentric resolve spontaneously in patient remains a enigma . Metabolic imbalance among patients at a different level associated with Reye ’s syndrome are still intriguing and puzzling .
Any child with Reye ’s syndrome who is unarousable to verbal stimuli or to light pain is think seriously ill , is treated immediately . Any defendant of unexpectednauseasensation after a viral malady like upper respiratory pamphlet contagion orchicken poxand mellow spirit level of liver enzyme ( SGOT - SGPT , usually 200 or more units ) in absence ofjaundice , immediate hospitalization insurance is significant for reducing the symptoms . Treatment for the metabolic imbalances and combat intracranial hypertension could result in the pure recuperation from Reye ’s syndrome .
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