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Multiple induration is a continuing , progressive autoimmune disorder require the central nervous system . It lead to demyelination of face ( in the brain , spinal cord and optic nerves ) , exposing them that causes deviant nerve impulse conduction .
Can MS Stop Your Periods?
Although , MS does not stop periods , it has quite a few result on menstrual periods and the effect of estrogen on MS . Observations have show that the progression of MS is favourable at the prison term of maternity . Studies have shown that there are reduced relapses in pregnancy , especially during the third trimester . This has been learn in retrogress prorogue type Ms. . The favorable issue on the relapse of MS could be attributed to the increased level of oestrogen during the last trimester . As we acknowledge that regress remitting MS progresses to secondary reform-minded MS in time . However , a full term pregnancy may in reality delay the handicap and the chances of advance to lower-ranking progressive MS .
The effect of MS on menstruate women is dissimilar . The fluctuation of hormones in women during catamenial cycle has been noted . There are exasperate of pre - menstrual symptoms occurring a week before the menstrual cycle . Some women with relapsing remitting case of MS have take down exacerbation or worsening of neurological symptom during menstruation phase angle . Recent subject field have also shown that the figure of lesion on MRI correspond directly to the endocrine of catamenial hertz .
It is still unclear why the symptom of MS fluctuate with menstrual cycle , although , evidence suggests a complex telling between hormone and immune system . The symptom of MS , which include fatigue , failing , proportion and depressive disorder , tend to get big prior to the onset of catamenial round . This could also be attributed to an increase in core body temperature before and during menstruum , which may worsen the MS symptom . If it is hard to deal with the worsen PMS symptoms in MS patients , antifertility pill or intrauterine gadget can be used to minimize these .
exacerbate of MS symptoms has also been noted during post partum period . This could be attributed to the fall in estrogen level in this period .
Menopause is also characterized by low estrogen levels and in menopausal females also the severity of neurological symptoms increases in MS patient . Some menopausal women have benefited from endocrine replacement therapy , which consists of oestrogen and shown improvement in MS symptom . However , the peril of hormone replacement therapy outweigh the benefit provided by them , so they should be used with caution and only in selected cases after an OK by MS healthcare professional .
Causes Of MS
The exact cause of MS is still unknown . It is considered an autoimmune disease , which leads to inflammation along with memorial tablet and wound that help name the disease on anMRI . The inflammation and wound on nerve sheath cause interruption in the conduction of impulses . The inflame lesion lead to scarring of myelin sheath , known as sclerosis . As they occur in various portions of the face throughout the soundbox , they are known as multiple sclerosis .
The exact effort of antibody attack the nerve sheath is unknown and is consider as a result of combination of various risk factors .
Lack OfSunlight . MS is more ordinarily see in people who hold up aside from equator and this could directly fit to lack of sun in individuals be farther from equator
distaff . MS is 2 - 3 times more vulgar in female person than in males and the cause for this is also unknown
Genes . Although , it is not a directly inherited disease , first - degree relatives are more likely and at a greater risk than normal population to get the disease ( the risk increases to about 2 - 5 % )
Infections . It is involve that Epstein Barr virus may be creditworthy for trigger off car - antibodies leading to MS
fume . The chance of MS increase about two flexure in somebody who fume compared to those who do not smoke
Although , it has been know to pass due to interplay between the autoimmune , environmental and genetical factor ; hormonal factors are also suggest to touch MS agree to recent studies .
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References :
https.//www.ncbi.nlm.nih.gov / pubmed/29455074
