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Can Morphea Turn Into Systemic Scleroderma?
normally morphea involves the skin , subcutaneous tissue and rarely the muscles and joint . Usually internal electric organ are not affect by morphea and it is very rarified for morphea to pass on into systemic dermatosclerosis . There are only very few case report , even in those cases it is not confirmed if they really had morphea in the first place .
Morphea that involves the subcutaneous tissue paper can extend into the muscle layers and rarely can involve the internal organs , but this very rare . If you have morphea you are not at increased risk of gravel systemic scleroderma although both conditions have similar etiology .
A study done in Italy “ From Localized Scleroderma to Systemic Sclerosis . Coexistence or Possible Evolution ” on 330 patients diagnosed with systemic sclerosis find that 8 female patients had both systemic induration and morphea , 6 patients out of that formulate morphea before the ontogenesis of systemic induration . The study resolve that systemic sclerosis and morphea are two unlike clinical entity that can co - live together .
Morphea commonly goes away on its own within a duet of years ; however , the skin changes and the damage that occurred during the fighting point of the disease will be present even after morphea is cure . Sometimes there can be serious disfigurations and skin color change present .
Let us see what is morphea and scleroderma is .
Morphea . Morphea is a focalise type of scleroderma which occurs due to excessive deposition of collagen in the deeper layers of the peel ( dermis and/or subcutaneous tissue ) . Systemic induration have such asRaynaud phenomenon , sclerodactyly , telangiectasia and involvement of the inner organ are absent in morphea . The relative incidence of morphea is around 0.4 - 2.7 cases per 100,000 people in the United states . It ’s go through in almost all races , but common in Whites and all forms of morphea are common in female person . Morphea can be seen at any geezerhood but more unwashed from the age 2 - 14 years and in the mid 40 ’s .
There are 3 types of unlike sub family of morphea , this is separate allot to the patter and the depth of tissue paper involve .
The precise etiology of morphea is unknown , it is said that an autoimmune status due to the gain production of autoantibody in the body might be the cause . Most of the patient role with morphea have other autoimmune disease and have electropositive serology test for other motorcar immune disease .
The following are believed to be some of the causes and associations
Systemic Scleroderma . Systemic scleroderma ( systemic sclerosis ) is a continuing connective tissue disease which is categorized under autoimmune rheumatic diseases . The incidence of scleroderma in the United States is about 20 cases per million universe . Roughly 300,000 typeface every class are diagnose with scleroderma . focalize genus Scleroderma ( morphea ) is more vulgar in children and systemic scleroderma is more common in adults and overall genus Scleroderma is seen more in females than in males ( 4.1 )
The accurate reason for scleroderma is not known but believed to be an autoimmune condition which induce excess collagen production . Systemic genus Scleroderma is multi - organ disease which affects most of the organs in the trunk . It causes tissue mark , abnormal connective tissue paper growths in muscles and joints , harm to bloodline vessels . It affects the skin , subcutaneous layer of the skin , muscular tissue , joints and internal organs such as centre , lung , GI tract and kidneys .
Conclusion
Morphea which is a localise type of genus Scleroderma occurs due to excessive deposition of collagen in the deeper level of the cutis ( dermis and/or subcutaneous tissue ) . Systemic dermatosclerosis ( systemic induration ) is a inveterate connective tissue paper disease , which is categorized under autoimmune rheumatoid disease . It is a multi - organ disease which affects the skin , subcutaneous layers of the skin , brawn , joints and internal organs such as tenderness , lung , gastrointestinal tract and kidney . normally morphea involves the skin , hypodermic tissue and rarely the muscles and joint . Usually internal organs are not affected by morphea and its very rarified for morphea to work up into systemic genus Scleroderma .
reference :
“ Localized Scleroderma ( Morphea ) and Systemic Scleroderma ( Systemic Sclerosis ) ” – American College of Rheumatologyhttps://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Scleroderma
“ From Localized Scleroderma to Systemic Sclerosis : Coexistence or Possible Evolution ” – Research clause [ supply DOI or Link if available ]
“ Systemic Sclerosis ( Scleroderma ) ” – Cleveland Clinichttps://my.clevelandclinic.org/health/diseases/17552-scleroderma-systemic-sclerosis
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